PXD041317
PXD041317 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Functional differences of experimental arthritis splenic macrophages in DA and DAMut rats are revealed by quantitative proteomics |
| Description | Rheumatoid arthritis (RA) is a devastating chronic inflammatory disorder affecting 0.5-1.0% of adults worldwide and is characterized by autoimmune reactivity and persistent active inflammation with concurrent tissue destruction. Animal models of RA provide an opportunity to understand disease pathogenesis and develop new therapeutic strategies . The DA inbred rat is commonly used in autoimmunity research due to its high susceptibility to several chronic inflammatory disorders such as arthritis and experimental autoimmune encephalomyelitis (EAE). The experimental arthritis induced by pristane, the arthritogenic component in mineral oil, in the DA rat can be classified with RA criteria, including a chronic relapsing disease course 5, 6. We have identified a mutation DA rat and the mutation plays a completely protective function in DA rats against EAE and pristane-induced arthritis (PIA). Macrophages are an essential source of pro-inflammatory cytokines in chronic inflammation and the progressive destruction of synovial joints. To elucidate the molecular mechanism by which the mutation regulates macrophage activation, we made quantitative mass spectrometry on the four groups of splenic macrophages: DA-control, DAMut-control, DA-PIA, DAMut-PIA. |
| HostingRepository | iProX |
| AnnounceDate | 2023-04-04 |
| AnnouncementXML | Submission_2023-04-03_20:30:09.645.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaowei Li |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-04-03 20:29:56 | ID requested | |
| ⏵ 1 | 2023-04-03 20:30:09 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: rat, pristane-induced arthritis, splenic macrophages |
Contact List
| Liesu Meng | |
|---|---|
| contact affiliation | Xi'an jiaotong university |
| contact email | mengliesu@xjtu.edu.cn |
| lab head | |
| Xiaowei Li | |
| contact affiliation | Xi'an jiaotong university |
| contact email | lixiaowei2021@xjtu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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