PXD041263 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dynamic Remodeling of Escherichia coli Interactome in Response to Environmental Perturbations |
| Description | Here, we applied co-fractionation mass spectrometry and computational modeling to quantify and profile the interactions of ~2,000 proteins in the bacterium Escherichia coli cultured under ten distinct culture conditions. The resulting quantitative co-elution patterns revealed large-scale condition-dependent interaction remodeling among protein complexes involved in diverse biochemical pathways in response to the unique environmental challenges. Network-level analysis highlighted interactome-wide biophysical properties and structural patterns governing interaction remodeling. Our results provide evidence of the local and global plasticity of the E. coli interactome. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-29 |
| AnnouncementXML | Submission_2025-11-29_02:22:30.568.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Carl White |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: NEWT:562; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-04-01 01:03:53 | ID requested | |
| ⏵ 1 | 2025-11-29 02:22:31 | announced | |
Publication List
| Youssef A, Bian F, Paniikov NS, Crovella M, Emili A, Dynamic remodeling of Escherichia coli interactome in response to environmental perturbations. Proteomics, 23(21-22):e2200404(2023) [pubmed] |
| 10.1002/pmic.202200404; |
Keyword List
| submitter keyword: LC-MSMS, TMT, Proteome, Interactome, CF/MS, Dynamic,E. coli |
Contact List
| Andrew Emili |
|---|
| contact affiliation | Center for Network Systems Biology, Boston University Knight Cancer Institute, Oregon Health and Science University |
| contact email | emili@ohsu.edu |
| lab head | |
| Carl White |
|---|
| contact affiliation | Boston University |
| contact email | cawhite@bu.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD041263 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041263
- Label: PRIDE project
- Name: Dynamic Remodeling of Escherichia coli Interactome in Response to Environmental Perturbations
