PXD041253 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | UBTF tandem duplication AMLs are sensitive to menin inhibition |
| Description | UBTF tandem duplications (TD) have recently emerged as a subtype-defining alteration in pediatric AML (pAML), which is characterized by HOXB gene dysregulation and a poor response to conventional chemotherapy. Here, we use protein-protein interaction studies to show that UBTF-TD maintains interactions with components of the RNA pol I complex, while also engaging with a network of unique protein interactors specific to UBTF-TD, like KMT2A. These data suggest that UBTF-TD both preserves canonical UBTF functions and demonstrates gain of function activities. Furthermore, we show that UBTF-TD and KMT2A co-localize to key genomic targets dysregulated in UBTF-TD leukemias, like HOXB gene clusters and MEIS1. Using a protein degradation system, we show that stemness, proliferation, and the HOXB molecular signature are dependent on sustained UBTF-TD localization to chromatin. Finally, we show UBTF-TD leukemias are sensitive to menin inhibition—providing a viable therapeutic strategy for children with this high-risk AML subtype |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-06 |
| AnnouncementXML | Submission_2025-11-06_08:34:01.332.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Evangelia Papachristou |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-03-31 06:45:45 | ID requested | |
| ⏵ 1 | 2025-11-06 08:34:01 | announced | |
Publication List
Keyword List
| submitter keyword: KMT2A, leukemia, manin,UBTF, qPLEX-RIME |
Contact List
| Jeffery M. Klco |
|---|
| contact affiliation | 1. Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, US. 2. Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis, TN, US. |
| contact email | jeffery.klco@stjude.org |
| lab head | |
| Evangelia Papachristou |
|---|
| contact affiliation | Senior Scientific Assistant |
| contact email | eva.papachristou@cruk.cam.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041253
- Label: PRIDE project
- Name: UBTF tandem duplication AMLs are sensitive to menin inhibition
