PXD041243 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma protein profiling of women after a GDM pregnancy |
Description | Gestational diabetes (GDM) is a distinctive form of diabetes that first presents in pregnancy. While most women return to normoglycemia after delivery, they are predisposed to an accelerated development of type 2 diabetes. Current prevention strategies remain limited due to our incomplete understanding of the early underpinnings of progression. We therefore examined the protein profiles of women shortly after a GDM pregnancy (using a nested case-control study design within the Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy) for a comprehensive mechanistic inquiry. At 6-9 weeks postpartum (baseline), differences between women who later developed diabetes (case group) and those who did not (control group) were detected. Notably, protein profiles comprised protease inhibitors, extracellular matrix components, and lipoprotein molecules involved in inflammation. We also identified co-expression networks of differentially altered triglycerides and protein involved in wound healing, highlighting the interplay between dyslipidemia and inflammation. Overall, our findings warrant earlier intervention than previously thought, as defects in postpartum wound healing after a GDM pregnancy, in association with dysmetabolism and insulin resistance, may accelerate type 2 diabetes progression. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-04 |
AnnouncementXML | Submission_2024-09-04_13:11:35.570.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Julie Anh Dung Van |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-31 01:58:43 | ID requested | |
⏵ 1 | 2024-09-04 13:11:36 | announced | |
Publication List
Keyword List
submitter keyword: females |
plasma |
discovery proteomics |
gestational diabetes,human |
Contact List
Michael Wheeler |
contact affiliation | Department of Physiology, University of Toronto, Toronto, Ontario, Canada |
contact email | michael.wheeler@utoronto.ca |
lab head | |
Julie Anh Dung Van |
contact affiliation | University of Toronto |
contact email | julie.van@mail.utoronto.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041243
- Label: PRIDE project
- Name: Plasma protein profiling of women after a GDM pregnancy