PXD041239

PXD041239 is an original dataset announced via ProteomeXchange.

Title	HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein
Description	Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. We demonstrated that the transcription factor, HOXC6, was overexpressed in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis. HOXC6 transcriptionally activated the tumor-promoting kinase MSK1. To identify the phosphorylation targets of MSK1 and the mediators of its function in AsPC1 cells, we utilized an unbiased TMT10-based phosphoproteomics analysis. To do so, we treated AsPC1 cells with MSK1 inhibitor SB-747651A and performed TMT10-based quantitative phosphoproteomics analysis and identified MSK1 phosphorylation targets.
HostingRepository	PRIDE
AnnounceDate	2023-10-31
AnnouncementXML	Submission_2023-10-30_18:32:03.336.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041239
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	narendrawajapeyee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-31 01:19:54	ID requested
⏵ 1	2023-10-30 18:32:03	announced

10.6019/PXD041239;

submitter keyword: pancreatic cancer, HOXC6, tumor growth, MSK1, metastasis

NarendraWajapeyee
contact affiliation	Professor and Vice Chairman for Research Department of Biochemistry and Molecular Genetics Co-Leader, Experimental Therapeutics Program UAB O'Neal Comprehensive Cancer Center Hugh Kaul Human Genetics Building, Kaul 504A The University of Alabama at Birmingham Birmingham, Alabama
contact email	nwajapey@uab.edu
lab head
narendrawajapeyee
contact affiliation	University of Alabama at Birmingham
contact email	nwajapey@uab.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041239
     1. Label: PRIDE project
     2. Name: HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein