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PXD041237

PXD041237 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHeat-killed probiotic Levilactobacillus brevis MRKAK9 downregulates insulin-signaling pathway and improves proteostasis and autophagy to promote longevity and immunity in Caenorhabditis elegans
DescriptionProbiotics play important role in maintaining the health and extend longevity in their host. Previous studies reported several live probiotic bacteria in enhancing longevity and improving diverse feature of the host’s health. In this study, we reported a new potential heat- killed probiotic bacterium Levilactobacillus brevis strain MRKAK9 improved longevity and different features of healthy aging, including age-associated physical activity, improved resistance to biotic and abiotic stress in C. elegans. The mechanistic investigations showed that heat-killed strain MRKAK9 promoted longevity and healthy aging by downregulating insulin-signaling pathway resulting in improved proteostasis, autophagy and preserving lysosomal functionality in C. elegans. Heat-killed strain MRKAK9-mediated downregulation of insulin signaling pathway was regulated by the miRNA mir-243, suggesting that mir-243 partially involved in enhancing longevity of C. elegans. Additionally, the structural component exopolysaccharide of the strain heat-killed MRKAK9 also downregulated insulin- signaling mechanisms, increased the expression of genes involved in proteostatsis, autophagy as well as improved expression of mir-243. This study indicates that heat-killed strain MRKAK9 improves longevity and healthy aging, suggesting its candidature as a novel postbiotic.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:54:08.359.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMojibur R. Khan
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-31 01:06:32ID requested
12024-08-10 12:04:40announced
22024-10-22 06:54:15announced2024-10-22: Updated project metadata.
Publication List
Kumar A, Saha MK, Kumar V, Bhattacharya A, Barge S, Mukherjee AK, Kalita MC, Khan MR, Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans. Immun Ageing, 21(1):52(2024) [pubmed]
10.1186/s12979-024-00457-w;
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Food and Nutrition (B/D-HPP), Human Proteome Project
submitter keyword: longevity
lactic acid bacteria
aging biomarkers
SKN-1 transcription factor
p38 MAPK signaling
behavior
intestinal integrity
Contact List
Dr. Mojibur R. Khan
contact affiliationAssociate Professor, Institute of Advanced Study in Science and Technology (IASST), Guwahati-110035, Assam, India
contact emailmblab.iasst@gmail.com
lab head
Mojibur R. Khan
contact affiliationInstitute of Advanced Studt in Science and Technology (IASST)
contact emailmblab.iasst@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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