PXD041200

PXD041200 is an original dataset announced via ProteomeXchange.

Title	ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Lenalidomde
Description	Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.
HostingRepository	PRIDE
AnnounceDate	2023-04-26
AnnouncementXML	Submission_2023-04-26_07:51:17.801.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	SabrinaKeller
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-30 02:25:53	ID requested
⏵ 1	2023-04-26 07:51:18	announced

Dataset with its publication pending

submitter keyword: EuBOPEN CRBN lenalidomide

MatthiasGstaiger
contact affiliation	ETHZ IMSB
contact email	gstaigem@ethz.ch
lab head
SabrinaKeller
contact affiliation	ETHZ IMSB
contact email	keller@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD041200

PRIDE project URI

• PRIDE
  1. PXD041200
     1. Label: PRIDE project
     2. Name: ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Lenalidomde