PXD041174

PXD041174 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Smooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate
Description	Cigarette smoke is a risk factor for inflammatory diseases, such as atherosclerosis. Tobacco smoke interacts with inflammatory cytokines to produce endothelial dysfunction and induces pro-inflammatory and pro-atherosclerotic effects in vascular tissue. Smooth muscle cells (SMCs) are present in the media of human arteries, and are considered protective against atherosclerotic plaque destabilization. Contractile SMCs are the most prominent cell type in the healthy vessel wall. SMCs are not terminally differentiated, and retain the ability to undergo a phenotypic switch from a contractile to a dedifferentiated synthetic state to express inflammatory markers and a phagocytic activity in response to environmental cues. The aim of our study was to evaluate the effects in human SMCs of lipophilic component from cigarette smoke condensate (CSC) and of hydrophilic components of Electronic-cigarette, Tobacco heating products, or cigarette smoke.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:47:47.003.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041174
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Stefano Bellosta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-28 18:49:07	ID requested
1	2023-05-10 15:03:27	announced
⏵ 2	2023-11-14 08:47:48	announced	2023-11-14: Updated project metadata.

Publication List

Bianchi L, Damiani I, Castiglioni S, Carleo A, De Salvo R, Rossi C, Corsini A, Bellosta S, Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview. Int J Mol Sci, 24(7):(2023) [pubmed]
10.6019/PXD041174;

Bianchi L, Damiani I, Castiglioni S, Carleo A, De Salvo R, Rossi C, Corsini A, Bellosta S, Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview. Int J Mol Sci, 24(7):(2023) [pubmed]

10.6019/PXD041174;

Keyword List

submitter keyword: Atherosclerosis
cigarette smoke
electronic cigarette
phenotypic switch
smooth muscle cells

submitter keyword: Atherosclerosis

cigarette smoke

electronic cigarette

phenotypic switch

smooth muscle cells

Contact List

Stefano Bellosta
contact affiliation	University of Milan, Faculty of Pharmacy, Department of Pharmacological and Biomolecular Science, 20133 Milan, ITALY
contact email	stefano.bellosta@unimi.it
lab head
Stefano Bellosta
contact affiliation	Università degli studi di Milano
contact email	stefano.bellosta@unimi.it
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD041174

PRIDE project URI

Repository Record List

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