PXD041171

PXD041171 is an original dataset announced via ProteomeXchange.

Title	Sirtuin 2 Promotes HCMV Replication by Regulating Cell Cycle Progression
Description	The host cell cycle is a major target for manipulation by viral pathogens, which often replicate in certain cell cycle stages. The prevalent pathogen human cytomegalovirus (HCMV), for instance, only replicates during G1 and therefore employs diverse mechanisms for regulating cell cycle progression. Here, we demonstrate that the human enzyme sirtuin 2 (SIRT2) is required for HCMV-mediated cell cycle dysregulation. By combining virology assays with mass pectrometry-based proteome, acetylome, and interactome analyses, we have defined a pro-virus function for SIRT2 in regulating the G1 to S phase transition.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:05:53.063.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cora Betsinger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-28 12:10:29	ID requested
1	2023-10-13 09:26:52	announced
2	2024-04-02 06:41:38	announced	2024-04-02: Updated project metadata.
⏵ 3	2024-10-22 06:05:54	announced	2024-10-22: Updated project metadata.

10.1128/msystems.00510-23;

Betsinger CN, Justice JL, Tyl MD, Edgar JE, Budayeva HG, Abu YF, Cristea IM, Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression. mSystems, 8(6):e0051023(2023) [pubmed]

submitter keyword: acetylation, human cytomegalovirus,sirtuin 2, cell cycle, protein-protein interactions

Ileana M. Cristea
contact affiliation	Princeton University
contact email	icristea@princeton.edu
lab head
Cora Betsinger
contact affiliation	Princeton University
contact email	corab@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD041171

PRIDE project URI

• PRIDE
  1. PXD041171
     1. Label: PRIDE project
     2. Name: Sirtuin 2 Promotes HCMV Replication by Regulating Cell Cycle Progression