PXD041155

PXD041155 is an original dataset announced via ProteomeXchange.

Title	Identification of Snf2L-associated chromatin remodeling complex subunits in Plasmodium falciparum
Description	ATP-dependent chromatin remodeling enzymes re-position and evict nucleosomes at specific genomic loci and therefore are essential regulators of all DNA dependent processes. They act in the context of large multiprotein complexes. The malaria-causing parasite Plasmodium falciparum (Pf) possesses a reduced set of chromatin remodeling enzymes, which are highly divergent, and no associated complex subunits are known. Within a detailed characterization of the ISWI-type remodeler PfSnf2L (PF3D7_1104200), potential interactors were identified. The protein was tagged endogenously in the parasite and co-immunoprecipitated. Subsequent LC-MS/MS analysis provided a list of specific protein interactors with a strong link to chromatin organization including nucleosome assembly factors, transcription factors as well as Plasmodium-specific uncharacterized proteins. The results suggest a functional role of PfSnf2L in nucleosome assembly and transcription regulation and point towards novel Plasmodium-specific chromatin remodeling complexes.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:08:18.745.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ignasi Forne
SpeciesList	scientific name: Plasmodium falciparum; NCBI TaxID: 5833;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-28 00:16:43	ID requested
⏵ 1	2024-10-17 05:08:19	announced

Dataset with its publication pending

submitter keyword: LC-MSMS, co-immunoprecipitation, malaria parasite,chromatin remodeling enzyme, ISWI, Plasmodium falciparum

Prof Dr Gernot Längst
contact affiliation	Universität Regensburg NWF III - Biologie/Vorklinische Medizin Institut für Biochemie, Genetik und Mikrobiologie
contact email	gernot.laengst@vkl.uni-regensburg.de
lab head
Ignasi Forne
contact affiliation	Biomedical Center-LMU
contact email	ignasi.forne@lrz.uni-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD041155

PRIDE project URI

• PRIDE
  1. PXD041155
     1. Label: PRIDE project
     2. Name: Identification of Snf2L-associated chromatin remodeling complex subunits in Plasmodium falciparum