PXD041113
PXD041113 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of thioredoxin 1 as a function target of the anti-resorptive agents |
| Description | Carabrone covalently binds to Trx1at cysteine 73 and then inhibits enzymatic activity, which inhibits differentiation and induces apoptosis in osteoclasts. Carabrone prevents bone resorption in vivo and in vitro. Targeting Trx1 represents a promising target for the treatment of bone-resorptive diseases. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-24 |
| AnnouncementXML | Submission_2023-05-30_18:55:49.871.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuting Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-26 21:49:17 | ID requested | |
| ⏵ 1 | 2023-05-30 18:55:50 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Osteoclast |
| Bone loss |
| Thioredoxin |
| Carabrone |
| Sesquiterpenoid |
Contact List
| Qiong Gu | |
|---|---|
| contact affiliation | Sun Yat-Sen University |
| contact email | guqiong@mail.sysu.edu.cn |
| lab head | |
| Yuting Zhang | |
| contact affiliation | Sun Yat-Sen University |
| contact email | zhangyt56@mail2.sysu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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