PXD041081 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Iberdomide |
Description | Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project. |
HostingRepository | PRIDE |
AnnounceDate | 2023-04-26 |
AnnouncementXML | Submission_2023-04-26_06:05:50.387.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | SabrinaKeller |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | biotinylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-24 01:05:49 | ID requested | |
⏵ 1 | 2023-04-26 06:05:50 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: EuBOPEN CRBN iberdomide |
Contact List
MatthiasGstaiger |
contact affiliation | ETHZ IMSB |
contact email | gstaigem@ethz.ch |
lab head | |
SabrinaKeller |
contact affiliation | ETHZ IMSB |
contact email | keller@imsb.biol.ethz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD041081 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041081
- Label: PRIDE project
- Name: ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Iberdomide