PXD041068

PXD041068 is an original dataset announced via ProteomeXchange.

Title	ChemBioID - An integrated chemical biology workflow for the analysis of inhibitor induced USP21 target proximity
Description	Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This EUbOPEN project is a collaboration between ETHZ and UTOR which aims to identify target protein proximity induced by USP21 inhibitors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:44:57.805.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthias Gstaiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-23 10:26:50	ID requested
1	2023-04-25 08:59:37	announced
⏵ 2	2024-10-22 05:44:58	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: USP21, EUbOPEN, BioID

Matthias Gstaiger
contact affiliation	ETH Zurich Dr. Matthias Gstaiger Institute of Molecular Systems Biology HPM F43 Otto-Stern-Weg 3 8093 Zürich Switzerland
contact email	gstaigem@ethz.ch
lab head
Matthias Gstaiger
contact affiliation	Institute of Molecular Systems Biology, ETH
contact email	gstaigem@ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD041068

PRIDE project URI

• PRIDE
  1. PXD041068
     1. Label: PRIDE project
     2. Name: ChemBioID - An integrated chemical biology workflow for the analysis of inhibitor induced USP21 target proximity