PXD040985
PXD040985 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Beta-hydroxybutyrate is a metabolic regulator of proteostasis in aging and Alzheimer disease |
| Description | Beta-hydroxybutyrate (BHB) is a ketone body whose signaling effects are not well characterized. The Newman Lab has observed a shift in brain cellular protein solubility following BHB treatment in vitro and in vivo. In the brains of C57BL/6 mice that received a 7-day oral gavage of ketone ester, we have observed formation of insoluble aggregates compared to control (canola oil). In a separate analysis, we treated soluble neuronal lysate from older C57BL/6 mice with multiple concentrations of R-BHB, then separated the proteins which become insolubilized. Here we seek to understand the composition of these insoluble aggregates by mass spectrometry and which proteins remain soluble, as a function of R-BHB treatment concentration. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-11-13 |
| AnnouncementXML | Submission_2024-11-13_11:08:37.605.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Christina King |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-20 16:35:00 | ID requested | |
| ⏵ 1 | 2024-11-13 11:08:37 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: proteostasis, insoluble aggregates, proteomics, DIA-MS, Beta-hydroxybutyrate (BHB) treatment |
Contact List
| Birgit Schilling | |
|---|---|
| contact affiliation | Buck Institute |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Christina King | |
| contact affiliation | Buck Institute for Research on Aging |
| contact email | cking@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000091514/ |
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