PXD040973

PXD040973 is an original dataset announced via ProteomeXchange.

Title	EZH2 inhibition induces HLA class I re-expression in Merkel Cell Carcinoma
Description	We hypothesized that EZH2 could be involved in immune escape in Merkel Cell Carcinoma (MCC). In this context, we aimed at evaluating whether EZH2 might contribute to HLA-I expression repression in MCC. To this purpose, we first investigated whether low/lack of HLA-I expression is associated with high H3K27me3 levels in MCC tumor samples. Whole proteome analysis of the PeTa cell line by mass spectrometry after DZNeP treatment (EZH2 inhibitor) revealed upregulation of proteins involved in Fc receptor, as well as antigen processing and presentation pathways components.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:15:23.022.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Etienne Coyaud
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-20 03:31:21	ID requested
1	2023-11-21 02:10:31	announced
⏵ 2	2024-10-22 06:15:23	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: whole proteome analysis, HLA, Polyomavirus,Merkel cell carcinoma, immunohistochemistry, EZH2

Etienne Coyaud
contact affiliation	Department of Biology, Univ. Lille, Inserm, CHU Lille, U1192-Protéomique Réponse Inflammatoire Spectrométrie de Masse-PRISM,, Lille, FR
contact email	etienne.coyaud@inserm.fr
lab head
Etienne Coyaud
contact affiliation	Univ. Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France
contact email	etienne.coyaud@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD040973

PRIDE project URI

• PRIDE
  1. PXD040973
     1. Label: PRIDE project
     2. Name: EZH2 inhibition induces HLA class I re-expression in Merkel Cell Carcinoma