PXD040931 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Role of 4EBP1/2 in the response to glucose deprivation |
Description | We investigated the function of the mTORC1 substrates and mRNA translation regulators 4EBP1/2 in the response to glucose deprivation. We uncovered that targeting 4EBP1/2 expression had a direct impact on the survival rates of cells challenged with glucose deprivation. To further define the mechanisms underlying 4EBP1/2 function under glucose deprivation, we conducted a proteomics analysis of HEK293 shRNA control and HEK293 shRNA 4EBP1/2 grown in basal media or under glucose deprivation (1 mM glucose containing media) for 30 hours. |
HostingRepository | PRIDE |
AnnounceDate | 2024-03-28 |
AnnouncementXML | Submission_2024-03-28_11:02:28.651.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Anja Stefanski |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-17 03:32:14 | ID requested | |
⏵ 1 | 2024-03-28 11:02:29 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: glucose starvation, stress response, 4EBP1/2, mRNA translation,mTORC1 |
Contact List
Kai Stühler |
contact affiliation | Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany |
contact email | kai.stuehler@hhu.de |
lab head | |
Anja Stefanski |
contact affiliation | Molecular Proteomics Laboratory |
contact email | anja.stefanski@hhu.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040931
- Label: PRIDE project
- Name: Role of 4EBP1/2 in the response to glucose deprivation