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PXD040931

PXD040931 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRole of 4EBP1/2 in the response to glucose deprivation
DescriptionWe investigated the function of the mTORC1 substrates and mRNA translation regulators 4EBP1/2 in the response to glucose deprivation. We uncovered that targeting 4EBP1/2 expression had a direct impact on the survival rates of cells challenged with glucose deprivation. To further define the mechanisms underlying 4EBP1/2 function under glucose deprivation, we conducted a proteomics analysis of HEK293 shRNA control and HEK293 shRNA 4EBP1/2 grown in basal media or under glucose deprivation (1 mM glucose containing media) for 30 hours.
HostingRepositoryPRIDE
AnnounceDate2024-03-28
AnnouncementXMLSubmission_2024-03-28_11:02:28.651.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnja Stefanski
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-17 03:32:14ID requested
12024-03-28 11:02:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: glucose starvation, stress response, 4EBP1/2, mRNA translation,mTORC1
Contact List
Kai Stühler
contact affiliationMolecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany
contact emailkai.stuehler@hhu.de
lab head
Anja Stefanski
contact affiliationMolecular Proteomics Laboratory
contact emailanja.stefanski@hhu.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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