PXD040930 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human Pancreatic Ductal Adenocarcinoma (PDAC), LC-MS/MS |
Description | The aim of the study was to characterize a common molecular mechanism for paclitaxel resistance in Patu-T and Suit-2.028 PDAC cell lines. Despite the ATP-binding cassette (ABC) trasnsporters were already shown to be involved in various chemo-resistant forms of cancers but not in PDAC, the most likely impact of ABCB1 overexpression in PDAC cell models was taken into account in this dataset. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:26:58.276.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD040930 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Francesco Finamore |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-17 02:43:12 | ID requested | |
1 | 2024-01-26 09:15:33 | announced | |
⏵ 2 | 2024-10-22 06:26:59 | announced | 2024-10-22: Updated project metadata. |
Publication List
Bergonzini C, Gregori A, Hagens TMS, van der Noord VE, van de Water B, Zweemer AJM, Coban B, Capula M, Mantini G, Botto A, Finamore F, Garajova I, McDonnell LA, Schmidt T, Giovannetti E, Danen EHJ, ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells. J Exp Clin Cancer Res, 43(1):4(2024) [pubmed] |
10.1186/s13046-023-02879-8; |
10.6019/PXD040930; |
Keyword List
submitter keyword: Human, PDAC cell models, Pancreas, LC-MS/MS |
Contact List
Elisa Giovannetti |
contact affiliation | Cancer Pharmacology Lab, Fondazione Pisana per la Scienza, San Giuliano, Pisa, Italy |
contact email | e.giovannetti@vumc.nl |
lab head | |
Francesco Finamore |
contact affiliation | Fondazione Pisana per la Scienza ONLUS |
contact email | f.finamore@fpscience.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD040930 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040930
- Label: PRIDE project
- Name: Human Pancreatic Ductal Adenocarcinoma (PDAC), LC-MS/MS