PXD040913
PXD040913 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism |
Description | Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. We use multiplex proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, to identify Complement Factor H Related Protein 5 (CFHR5), a regulator of the alternative pathway of complement activation, as a novel VTE associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-03 |
AnnouncementXML | Submission_2024-10-03_07:24:34.948.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | David Kotol |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-03-16 04:40:45 | ID requested | |
1 | 2023-03-25 02:54:06 | announced | |
⏵ 2 | 2024-10-03 07:24:36 | announced | 2024-10-03: Updated project metadata. |
Publication List
10.1038/s41467-023-38383-y; |
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmstr, ö, m M, Magnusson M, Silveira A, Uhl, é, n M, Renn, é T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Tr, é, gou, ë, t DA, Odeberg J, Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nat Commun, 14(1):3280(2023) [pubmed] |
Keyword List
submitter keyword: Human, blood plasma, venous thromboelism, complement factor |
Contact List
Jacob Odeberg | |
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contact affiliation | Science for Life Laboratory, Department of Protein Science, CBH, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden |
contact email | jacob.odeberg@scilifelab.se |
lab head | |
David Kotol | |
contact affiliation | KTH - SciLifeLab |
contact email | david.kotol@scilifelab.se |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD040913 |
PRIDE project URI |
Repository Record List
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