PXD040913

PXD040913 is an original dataset announced via ProteomeXchange.

Title	Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism
Description	Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. We use multiplex proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, to identify Complement Factor H Related Protein 5 (CFHR5), a regulator of the alternative pathway of complement activation, as a novel VTE associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.
HostingRepository	PRIDE
AnnounceDate	2023-03-25
AnnouncementXML	Submission_2023-03-25_02:54:06.583.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	DavidKotol
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-16 04:40:45	ID requested
⏵ 1	2023-03-25 02:54:06	announced

Dataset with its publication pending

submitter keyword: Human, blood plasma, venous thromboelism, complement factor

JacobOdeberg
contact affiliation	Science for Life Laboratory, Department of Protein Science, CBH, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden
contact email	jacob.odeberg@scilifelab.se
lab head
DavidKotol
contact affiliation	KTH - SciLifeLab
contact email	david.kotol@scilifelab.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD040913
     1. Label: PRIDE project
     2. Name: Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism