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PXD040908

PXD040908 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMorphological change of gill and activation of cell phagocytosis pathway through differential proteomics in Mytilus coruscus under starvation
DescriptionMytilus coruscus are one of the dominant shellfish in the Yangtze estuary, but they often face food deprivation due to seasonal fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture. To investigate the coping strategies of M. coruscus to starvation stress, electron microscopy and differential proteomic analysis were performed on the important feeding organ gill of the mussels after 9 d of starvation stress. The electron microscopy results showed that the cilia of the mussel were dissolved and the gill filament gap was widened under starvation. The results of differential proteomic analysis showed that phagocytosis-related proteins ATPeV1E, ATPeV1C, LAMP1_2 and CTSL were significantly upregulated, combined with a significant increase in myeloperoxidase (MPO) in mussel blood and a large number of dead cells in blood, which led to the conclusion that the mussel responded to the starvation environment by changing the gill tissue structure on the one hand, and by activate cell phagocytosis pathway on the other hand. The results showed that the M. coruscus respond to starvation by changing the gill structure and recycling energy and nutrients from dead cells through phagocytosis. In addition, proteomic data suggest that M. coruscus starvation tolerance traits are related to immune maintenance, cellular transport and metabolism. These studies suggest that phagocytosis is an important strategy for mussels to cope with starvation, which providing new scientific knowledge and theoretical basis for understanding the adaptation mechanisms of M. coruscus to starvation tolerance and for rational optimization of mussel culture patterns.
HostingRepositoryiProX
AnnounceDate2023-03-16
AnnouncementXMLSubmission_2023-04-18_19:20:47.687.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZewei Liang
SpeciesList scientific name: Mytilus coruscus; NCBI TaxID: 42192;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-15 22:46:42ID requested
12023-03-15 22:47:15announced
22023-04-18 19:20:48announced2023-04-19: Update publication information.
Publication List
Liang ZW, Li SY, Zhang XL, Chen CY, Sun WJ, Gu ZQ, Huang J, He JY, Qi PZ, Guo BY, Liao Z, Yan XJ, under starvation. Front Physiol, 14():1150521(2023) [pubmed]
Keyword List
submitter keyword: Mytilus coruscus, starvation stress, gill, morphological structure
phagocytosis, differential proteomics
Contact List
Xiaolin Zhang
contact affiliationZhe Jiang Ocean University
contact emailzhangxiaolin@zjou.edu.cn
lab head
Zewei Liang
contact affiliationZhe Jiang Ocean University
contact email841466983@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI