PXD040908
PXD040908 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Morphological change of gill and activation of cell phagocytosis pathway through differential proteomics in Mytilus coruscus under starvation |
Description | Mytilus coruscus are one of the dominant shellfish in the Yangtze estuary, but they often face food deprivation due to seasonal fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture. To investigate the coping strategies of M. coruscus to starvation stress, electron microscopy and differential proteomic analysis were performed on the important feeding organ gill of the mussels after 9 d of starvation stress. The electron microscopy results showed that the cilia of the mussel were dissolved and the gill filament gap was widened under starvation. The results of differential proteomic analysis showed that phagocytosis-related proteins ATPeV1E, ATPeV1C, LAMP1_2 and CTSL were significantly upregulated, combined with a significant increase in myeloperoxidase (MPO) in mussel blood and a large number of dead cells in blood, which led to the conclusion that the mussel responded to the starvation environment by changing the gill tissue structure on the one hand, and by activate cell phagocytosis pathway on the other hand. The results showed that the M. coruscus respond to starvation by changing the gill structure and recycling energy and nutrients from dead cells through phagocytosis. In addition, proteomic data suggest that M. coruscus starvation tolerance traits are related to immune maintenance, cellular transport and metabolism. These studies suggest that phagocytosis is an important strategy for mussels to cope with starvation, which providing new scientific knowledge and theoretical basis for understanding the adaptation mechanisms of M. coruscus to starvation tolerance and for rational optimization of mussel culture patterns. |
HostingRepository | iProX |
AnnounceDate | 2023-03-16 |
AnnouncementXML | Submission_2023-04-18_19:20:47.687.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zewei Liang |
SpeciesList | scientific name: Mytilus coruscus; NCBI TaxID: 42192; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-03-15 22:46:42 | ID requested | |
1 | 2023-03-15 22:47:15 | announced | |
⏵ 2 | 2023-04-18 19:20:48 | announced | 2023-04-19: Update publication information. |
Publication List
Liang ZW, Li SY, Zhang XL, Chen CY, Sun WJ, Gu ZQ, Huang J, He JY, Qi PZ, Guo BY, Liao Z, Yan XJ, under starvation. Front Physiol, 14():1150521(2023) [pubmed] |
Keyword List
submitter keyword: Mytilus coruscus, starvation stress, gill, morphological structure |
phagocytosis, differential proteomics |
Contact List
Xiaolin Zhang | |
---|---|
contact affiliation | Zhe Jiang Ocean University |
contact email | zhangxiaolin@zjou.edu.cn |
lab head | |
Zewei Liang | |
contact affiliation | Zhe Jiang Ocean University |
contact email | 841466983@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |