PXD040902

PXD040902 is an original dataset announced via ProteomeXchange.

Title	Determination of protein monoclonal-antibody epitopes by a combination of structural proteomics methods.
Description	We use a combination of multiple structural proteomics techniques (differential photo-reactive surface modification, HDX, crosslinking and epitope excision/extraction) for the determination of the protein antigen epitopes for monoclonal antibodies.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:09:30.429.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evgeniy Petrotchenko
SpeciesList	scientific name: HIV-1 M:B_MN; NCBI TaxID: 11696;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-15 16:44:58	ID requested
1	2023-10-24 12:06:27	announced
2	2023-11-14 09:08:35	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:09:31	announced	2024-10-22: Updated project metadata.

10.1021/acs.jproteome.3c00159;

Petrotchenko EV, Nascimento EM, Witt JM, Borchers CH, Determination of Protein Monoclonal-Antibody Epitopes by a Combination of Structural Proteomics Methods. J Proteome Res, 22(9):3096-3102(2023) [pubmed]

submitter keyword: HDX, limited proteolysis,surface modification, crosslinking

Christoph Borchers
contact affiliation	Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada3Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
contact email	christoph.borchers@mcgill.ca
lab head
Evgeniy Petrotchenko
contact affiliation	SCPC, LDI, JGH, McGill University
contact email	jenyavp@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD040902

PRIDE project URI

• PRIDE
  1. PXD040902
     1. Label: PRIDE project
     2. Name: Determination of protein monoclonal-antibody epitopes by a combination of structural proteomics methods.