PXD040888 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | RNA polymerase II acts to promote the organization of chromatin following DNA replication |
Description | In mammals, following the passage of the replisome, nucleosomes lose their defined positioning and transcription contributes to their re-organisation. However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear.
The data uploaded are associated to the iPOND-TMT data uploaded under PXD046514 where protein re-association to newly replicated DNA was monitored upon transcription inhibition. To see whether changes observed in the iPOND-TMT time course experiments (PXD046514) are due to changes in overall protein abundance, whole extract samples were taken for each time point (Nascent, 1h and 2h after EdU labelling) and analysed by TMT-Mass Spec. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:29:30.047.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Susanne Bandau |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-15 04:31:43 | ID requested | |
1 | 2024-02-14 07:36:36 | announced | |
⏵ 2 | 2024-10-22 06:29:31 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s44319-024-00085-x; |
Bandau S, Alvarez V, Jiang H, Graff S, Sundaramoorthy R, Gierlinski M, Toman M, Owen-Hughes T, Sidoli S, Lamond A, Alabert C, RNA polymerase II promotes the organization of chromatin following DNA replication. EMBO Rep, 25(3):1387-1414(2024) [pubmed] |
Keyword List
submitter keyword: TMT,Proteomics, DNA replications |
Contact List
Constance Alabert |
contact affiliation | Centre for Gene Regulation and Expression, School of Life Science, University of Dundee |
contact email | c.alabert@dundee.ac.uk |
lab head | |
Susanne Bandau |
contact affiliation | University of Dundee |
contact email | sbandau@dundee.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD040888 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040888
- Label: PRIDE project
- Name: RNA polymerase II acts to promote the organization of chromatin following DNA replication