PXD040876
PXD040876 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global quantitative analysis of proteomic of mice with liver fibrosis based on DIA and PRM technology |
| Description | Liver fibrosis (LF) is a kind of progressive liver injury reaction. The goal of this study was to achieve a more detailed understanding of the molecular changes in response to CCl4-induced LF through the identification of a differentially expressed liver proteomic. A total of 302 differentially expressed proteins (DEPs) were significantly identified at the proteomic level. Importantly,Gstm1, Gstm3, Ephx1 and Gstp1 were shown to be associated with metabolic pathways, and parallel reaction monitoring (PRM) verification showed that the results were consistent with those of data -independent acquisition (DIA). Through the analysis of proteomic data, this study provides valuable insights into the potential mechanism of the pathogenesis of LF, and lays a theoretical foundation for the further development of targeted therapy for LF. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-14 |
| AnnouncementXML | Submission_2025-02-25_18:43:35.523.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hui Jiang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-14 19:33:42 | ID requested | |
| ⏵ 1 | 2025-02-25 18:43:36 | announced |
Publication List
| Zhang L, Zhou Q, Zhang J, Cao K, Fan C, Chen S, Jiang H, Wu F, Liver transcriptomic and proteomic analyses provide new insight into the pathogenesis of liver fibrosis in mice. Genomics, 115(6):110738(2023) [pubmed] |
Keyword List
| submitter keyword: liver fibrosis, Proteomics, data independent acquisition, parallel reaction monitoring |
Contact List
| Hui Jiang | |
|---|---|
| contact affiliation | Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China |
| contact email | jianghui@ahtcm.edu.cn |
| lab head | |
| Hui Jiang | |
| contact affiliation | Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China |
| contact email | jianghui@ahtcm.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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