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PXD040876

PXD040876 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal quantitative analysis of proteomic of mice with liver fibrosis based on DIA and PRM technology
DescriptionLiver fibrosis (LF) is a kind of progressive liver injury reaction. The goal of this study was to achieve a more detailed understanding of the molecular changes in response to CCl4-induced LF through the identification of a differentially expressed liver proteomic. A total of 302 differentially expressed proteins (DEPs) were significantly identified at the proteomic level. Importantly,Gstm1, Gstm3, Ephx1 and Gstp1 were shown to be associated with metabolic pathways, and parallel reaction monitoring (PRM) verification showed that the results were consistent with those of data -independent acquisition (DIA). Through the analysis of proteomic data, this study provides valuable insights into the potential mechanism of the pathogenesis of LF, and lays a theoretical foundation for the further development of targeted therapy for LF.
HostingRepositoryiProX
AnnounceDate2023-03-14
AnnouncementXMLSubmission_2025-02-25_18:43:35.523.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHui Jiang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-14 19:33:42ID requested
12025-02-25 18:43:36announced
Publication List
Zhang L, Zhou Q, Zhang J, Cao K, Fan C, Chen S, Jiang H, Wu F, Liver transcriptomic and proteomic analyses provide new insight into the pathogenesis of liver fibrosis in mice. Genomics, 115(6):110738(2023) [pubmed]
Keyword List
submitter keyword: liver fibrosis, Proteomics, data independent acquisition, parallel reaction monitoring
Contact List
Hui Jiang
contact affiliationExperimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
contact emailjianghui@ahtcm.edu.cn
lab head
Hui Jiang
contact affiliationExperimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
contact emailjianghui@ahtcm.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI