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PXD040860

PXD040860 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMachine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome
DescriptionHLA-DQ molecules can be formed as both cis and trans variants. So far, the progress for predicting HLA-DQ antigen presentation has been limited. In addition, the contribution of trans-only variants in shaping the HLA-DQ immunopeptidome remains largely unresolved. Here, we address these issues by integrating state-of-the-art immunoinformatics data mining models with large volumes of high-quality HLA-DQ specific immunopeptidomics data. The analysis demonstrated a highly improved predictive power and molecular coverage for models trained with these novel HLA-DQ data and a limited to no contribution for trans-only HLA-DQ variants to the overall HLA-DQ immunopeptidome.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:47:58.973.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD040860
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHooman Yari
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monosodium salt; acetylated residue; monohydroxylated residue; deamidated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-14 08:58:03ID requested
12023-05-10 15:54:09announced
22023-11-14 08:48:07announced2023-11-14: Updated project metadata.
Publication List
Nilsson JB, Kaabinejadian S, Yari H, Peters B, Barra C, Gragert L, Hildebrand W, Nielsen M, Machine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome. Commun Biol, 6(1):442(2023) [pubmed]
10.6019/PXD040860;
Keyword List
submitter keyword: Machine learning, Immunopeptidome, HLA-DQ
Contact List
William Hildebrand
contact affiliationUniversity of Oklahoma Health Sciences Center
contact emailwilliam-hildebrand@ouhsc.edu
lab head
Hooman Yari
contact affiliationUniversity of Oklahoma Health Sciences Center
contact emailhooman-yari@ouhsc.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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