PXD040845

PXD040845 is an original dataset announced via ProteomeXchange.

Title	Temporal proteomic profiling reveals functional pathways in vaccinia-induced cell migration
Description	Viral diseases have alwanys been intricate and persistent issues throughout the world and lack of holistic discoveries of molecular dysregulations of virus-host interactions. The temporal proteomics strategy can identify various differentially expressed proteins and offer collaborated interaction networks under pathological conditions. Herein, temporal proteomics at various hours post infection of Vero cells were launched to uncover molecular alternations during vaccinia virus-induced cell migration. Different stages of infection were included to differentiate gene ontologies and critical pathways at specific time points of infection. The enrichment of functional interaction networks and pathways verified the significances of regulation of actin cytoskeleton and lamellipodia during vaccinia virus-induced fast cell motility. Current results offer the systematic proteomic profiling og molecular dysregulations at different stages of vaccinia virus infection and potential biomedical targets for treating viral diseases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:14.569.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiayin Lu
SpeciesList	scientific name: Chlorocebus sabaeus; NCBI TaxID: 60711;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-13 22:09:12	ID requested
1	2023-05-03 18:51:44	announced
⏵ 2	2023-11-14 09:01:15	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: host-virus interactions, cell migration, regulation of actin cytoskeleton, vaccinia virus,temporal proteomics

Jiayin Lu
contact affiliation	Department of chemistry, Fudan univerisity, Shanghai, China
contact email	20210220016@fudan.edu.cn
lab head
Jiayin Lu
contact affiliation	Fudan university
contact email	20210220016@fudan.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD040845
     1. Label: PRIDE project
     2. Name: Temporal proteomic profiling reveals functional pathways in vaccinia-induced cell migration