PXD040842
PXD040842 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Acute murine cytomegalovirus infection boosts cell-type specific response andlipid metabolism changes in infant mice liver |
| Description | Human cytomegalovirus (HCMV) infection in infants cause severe diseasessuch as neonata hepatitis, However, the single-cell dimensiona description otthe immune cel alteration during the first virus exposure process in infantsremains poorly understood. The hepatocytes play an essential role in metabolichomeostasis and detoxification, The Concomitant Effects of CMV infection oriver lipid metabolism in infants are still unclear. Here, using single-cell RNAsequencing, we found MCMV can infect most cell types of infant mice liverchanging the number of immune cells, MCMV infection increases proliferatincsubset of Nos2+CD8 effectorcells and amonocytes，which may plalimportant roles in the early anti-viral process. Furthermore, MCMV infectiorsubvert the protein expression profile of lipid metabolism in hepatocytesOverall, our data provide insights as to how the immune system response toMCMY infection during the early stage of infection, and the impact of infectionon lipid metabolism in infant mice hepatocvtes. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-13 |
| AnnouncementXML | Submission_2023-08-29_21:46:20.579.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Anmin Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | TMT6plex reporter fragment |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-13 19:53:14 | ID requested | |
| 1 | 2023-08-08 20:40:51 | announced | |
| ⏵ 2 | 2023-08-29 21:46:21 | announced | 2023-08-30: Update publication information. |
Publication List
| Gao J, Wang A, Bu X, Jia W, Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice. Front Immunol, 14():1169869(2023) [pubmed] |
Keyword List
| submitter keyword: mice, liver, MCMV |
Contact List
| Weidong Jia | |
|---|---|
| contact affiliation | University of Science and Technology of China |
| contact email | jwd1968@ustc.edu.cn |
| lab head | |
| Anmin Wang | |
| contact affiliation | University of Science and Technology of China |
| contact email | amwang13@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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