PXD040815
PXD040815 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synaptically recruited lncRNA SLAMR facilitates structural plasticity in fear memory consolidation by modulatin translation |
| Description | LncRNAs are involved in critical processes for cell homeostasis and function. However, it remains largely unknown whether and how the transcriptional regulation of long noncoding RNAs results in activity-dependent changes at the synapse and facilitate formation of long-term memories. Here, we report the identification of a novel lncRNA, SLAMR, that becomes enriched in CA1- but not in CA3-hippocampal neurons upon contextual fear conditioning. SLAMR is transported to dendrites via the molecular motor KIF5C and recruited to the synapse in response to stimulation. Loss of function of SLAMR reduced dendritic complexity and impaired activity-dependent changes in spine structural plasticity. Interestingly, the gain of function of SLAMR enhanced dendritic complexity, and spine density through enhanced translation. Analyses of the SLAMR interactome revealed its association with CaMKIIa protein through a 220-nucleotide element and its modulation of CaMKIIa activity. Furthermore, loss-of-function of SLAMR in CA1 selectively impairs consolidation but neither acquisition, recall, nor extinction of fear memory and spatial memory. Together, these results establish a new mechanism for activity dependent changes at the synapse and consolidation of contextual fear memory. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-03-08 |
| AnnouncementXML | Submission_2024-03-08_13:12:14.617.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | George Tsaprailis |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Oxidation; Deamidated; Carbamidomethyl |
| Instrument | Orbitrap Fusion ETD |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-13 09:19:48 | ID requested | |
| ⏵ 1 | 2024-03-08 13:12:14 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: lncRNA, translpot, plaricity, memory, hippocampus |
Contact List
| Sathyanarayanan Puthanveettil | |
|---|---|
| contact affiliation | The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology |
| contact email | sputhanveettil@ufl.edu |
| lab head | |
| George Tsaprailis | |
| contact affiliation | The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology |
| contact email | gtsaprailis@ufl.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000091477/ |
to receive all new ProteomeXchange dataset release announcements!
