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PXD040802

PXD040802 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAstrocyte-microglia interaction drives Aβ induced initial memory deficit
DescriptionBased on behavioral paradigms, olfactory memory impaiment was considered as the first congnitive decline symptom in 5xFAD mice at 4-month-old. Proteomes in olfactory memory associated brain region, piriform cortex, at different stages were analyzed. The results indiciated that proteins alterations at different stages are diverse, but the core regulatory network involved in AD pathogenesis is conservd. Microglia and astrocyte specific proteins are enriched in the networks and associated with glial cell activation in the initial cognitive impairment stage. It implied the mutual effect of the two glial cells plays an essential role in Aβ induced initial AD pathogenesis.
HostingRepositoryiProX
AnnounceDate2023-03-13
AnnouncementXMLSubmission_2024-03-11_01:17:39.656.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKefu Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-13 01:12:42ID requested
12023-03-13 01:12:56announced
22024-03-11 01:17:40announced2024-03-11: Update information.
Publication List
Liu K, Aierken A, Liu M, Parhat N, Kong W, Yin X, Liu G, Yu D, Hong J, Ni J, Quan Z, Liu X, Ji S, Mao J, Peng W, Chen C, Yan Y, Qing H, The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. iScience, 27(3):109281(2024) [pubmed]
Keyword List
submitter keyword: Alzheimer's disease, mass-spectrum based proteomics, memory deficit, piriform cortex
Contact List
Kefu Liu
contact affiliationCentral South University
contact emailliukefu@csu.edu.cn
lab head
Kefu Liu
contact affiliationCentral South University
contact emailliukefu@csu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI