PXD040802
PXD040802 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Astrocyte-microglia interaction drives Aβ induced initial memory deficit |
Description | Based on behavioral paradigms, olfactory memory impaiment was considered as the first congnitive decline symptom in 5xFAD mice at 4-month-old. Proteomes in olfactory memory associated brain region, piriform cortex, at different stages were analyzed. The results indiciated that proteins alterations at different stages are diverse, but the core regulatory network involved in AD pathogenesis is conservd. Microglia and astrocyte specific proteins are enriched in the networks and associated with glial cell activation in the initial cognitive impairment stage. It implied the mutual effect of the two glial cells plays an essential role in Aβ induced initial AD pathogenesis. |
HostingRepository | iProX |
AnnounceDate | 2023-03-13 |
AnnouncementXML | Submission_2024-03-11_01:17:39.656.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kefu Liu |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-03-13 01:12:42 | ID requested | |
1 | 2023-03-13 01:12:56 | announced | |
⏵ 2 | 2024-03-11 01:17:40 | announced | 2024-03-11: Update information. |
Publication List
Liu K, Aierken A, Liu M, Parhat N, Kong W, Yin X, Liu G, Yu D, Hong J, Ni J, Quan Z, Liu X, Ji S, Mao J, Peng W, Chen C, Yan Y, Qing H, The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. iScience, 27(3):109281(2024) [pubmed] |
Keyword List
submitter keyword: Alzheimer's disease, mass-spectrum based proteomics, memory deficit, piriform cortex |
Contact List
Kefu Liu | |
---|---|
contact affiliation | Central South University |
contact email | liukefu@csu.edu.cn |
lab head | |
Kefu Liu | |
contact affiliation | Central South University |
contact email | liukefu@csu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |