PXD040796

PXD040796 is an original dataset announced via ProteomeXchange.

Title	Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation
Description	Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments. However, the metabolic framework in cumulus cells has not been systematically described. In the present study, cumulus cells from cumulus-oocyte complexes (COCs) at three key time points were isolated, and the temporal metabolomic and proteomic profiling were performed. Integrated multi-omics analysis reveals the global metabolic patterns in cumulus cells during mouse oocyte maturation. In particular, we found the active hyaluronic acid metabolism, steroid hormone synthesis, and prostaglandin E2 (PGE2) production in cumulus cells. Meanwhile, accompanying the oocyte maturation, a progressive increase in nucleotide and amino acid metabolism were was detected in the surrounding cumulus cells. In addition, the comparison of metabolite changes between oocyte and cumulus cells implicates the metabolic coordination. In sum, the data serve as a valuable resource for probing follicular metabolism during follicular development, and provide the potential biomarkers for improving and predicting oocyte quality.
HostingRepository	iProX
AnnounceDate	2023-03-10
AnnouncementXML	Submission_2023-08-29_21:47:01.606.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yueshuai Guo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-12 20:03:49	ID requested
1	2023-08-09 23:30:38	announced
⏵ 2	2023-08-29 21:47:02	announced	2023-08-30: Update publication information.

Chen M, Yang W, Guo Y, Hou X, Zhu S, Sun H, Guo X, Chen M, Wang Q, Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation. J Ovarian Res, 16(1):156(2023) [pubmed]

submitter keyword: Cumulus cells, Oocyte, Metabolomics, Proteomics, Reproduction

Xuejiang Guo
contact affiliation	Nanjing Medical University
contact email	guo_xuejiang@njmu.edu.cn
lab head
Yueshuai Guo
contact affiliation	Nanjing Medical University
contact email	gys_706@163.com
dataset submitter

iProX dataset URI