PXD040761 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exploring the molecular mechanisms behind the potentiation of chemotherapy effects by durvalumab in lung adenocarcinoma cell lines |
Description | Immune checkpoint inhibitors are increasingly used in combination with chemotherapy for treatment of non-small cell lung cancer, yet the success of combination therapies is relatively limited. Thus, more detailed insight regarding the tumour molecular markers that may affect the responsiveness of patients to therapy is required. Here, we set out to explore the proteome of two lung adenocarcinoma cell lines (HCC-44 and A549) treated with cisplatin, pemetrexed, durvalumab, and the corresponding mixtures to establish the differences in post-treatment protein expression that can serve as markers of chemosensitivity or resistance. |
HostingRepository | PRIDE |
AnnounceDate | 2023-05-12 |
AnnouncementXML | Submission_2023-05-12_01:56:19.757.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | DarjaLavogina |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-10 02:11:56 | ID requested | |
⏵ 1 | 2023-05-12 01:56:20 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: chemosensitivity, proteomics, resistance,lung adenocarcinoma, pemetrexed, durvalumab, cisplatin |
Contact List
DarjaLavogina |
contact affiliation | University of Tartu, Institute of Chemistry |
contact email | darja.lavogina@ut.ee |
lab head | |
DarjaLavogina |
contact affiliation | University of Tartu |
contact email | darja.lavogina@ut.ee |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040761
- Label: PRIDE project
- Name: Exploring the molecular mechanisms behind the potentiation of chemotherapy effects by durvalumab in lung adenocarcinoma cell lines