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PXD040761

PXD040761 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExploring the molecular mechanisms behind the potentiation of chemotherapy effects by durvalumab in lung adenocarcinoma cell lines
DescriptionImmune checkpoint inhibitors are increasingly used in combination with chemotherapy for treatment of non-small cell lung cancer, yet the success of combination therapies is relatively limited. Thus, more detailed insight regarding the tumour molecular markers that may affect the responsiveness of patients to therapy is required. Here, we set out to explore the proteome of two lung adenocarcinoma cell lines (HCC-44 and A549) treated with cisplatin, pemetrexed, durvalumab, and the corresponding mixtures to establish the differences in post-treatment protein expression that can serve as markers of chemosensitivity or resistance.
HostingRepositoryPRIDE
AnnounceDate2023-05-12
AnnouncementXMLSubmission_2023-05-12_01:56:19.757.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDarjaLavogina
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-10 02:11:56ID requested
12023-05-12 01:56:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: chemosensitivity, proteomics, resistance,lung adenocarcinoma, pemetrexed, durvalumab, cisplatin
Contact List
DarjaLavogina
contact affiliationUniversity of Tartu, Institute of Chemistry
contact emaildarja.lavogina@ut.ee
lab head
DarjaLavogina
contact affiliationUniversity of Tartu
contact emaildarja.lavogina@ut.ee
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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