PXD040753

PXD040753 is an original dataset announced via ProteomeXchange.

Title	(−)-Vinigrol Targets PDI-ADAM17 Module to Induce TNFR1 Shedding and Ameliorate Rheumatoid Arthritis in Mice
Description	Our study indicates that targeting the PDI-ADAM17 signaling module to regulate the shedding of cytokine receptors by the chemical approach constitutes a novel strategy for alleviating RA
HostingRepository	iProX
AnnounceDate	2023-03-10
AnnouncementXML	Submission_2024-06-06_00:58:39.349.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yinhua Zhu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-09 21:42:07	ID requested
1	2023-03-09 21:44:06	announced
⏵ 2	2024-06-06 00:58:40	announced	2024-06-06: Update information.

Zhu Y, Wang L, Li J, Zhao Y, Yu X, Liu P, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z, Wang L, Luo T, Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice. Cell Chem Biol, 31(3):452-464.e10(2024) [pubmed]

submitter keyword: Vinigrol，rheumatoid arthritis，Protein Disulfide Isomerase，TNFR1 shedding

Tuoping Luo
contact affiliation	Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, Peking University
contact email	tuopingluo@pku.edu.cn
lab head
Yinhua Zhu
contact affiliation	Peking University
contact email	yhzhu@icmm.ac.cn
dataset submitter

iProX dataset URI