PXD040744

PXD040744 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Description	Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscale vesicles with bilayer lipid membrane released by almost all cell types. EVs are present in body fluids, including urine, blood and CSF. Cerebrospinal fluid(CSF) is a colorless fluid that surrounds the brain and spinal cord and acts as lymph in the central nervous system. CSF-derived EVs contain proteins from neurons, oligodendrocytes, astrocytes and microglias. Studies of CSF EVs are mainly limited by the amount of EVs isolated from per milliliter of CSF and the volume of CSF acquired from one patient. Here, we provide a label-free quantitative phospho-proteome profiling of EVs separated from PCNSL and non-PCNSL CSF samples by an earlier introduced functional magnetic beads called EVTRAP together with highly sensitive timsTOF Pro.
HostingRepository	jPOST
AnnounceDate	2023-07-12
AnnouncementXML	Submission_2023-07-11_08:00:48.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuanyuan Deng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	alpha-amino acetylated residue; S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-09 18:02:59	ID requested
⏵ 1	2023-07-11 08:00:49	announced

Publication List

Deng Y, Li Q, Sun J, Ma L, Ding Y, Cai Y, Iliuk A, Chen B, Xie Z, Tao WA, Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. Analyst, 148(15):3594-3602(2023) [pubmed]

Deng Y, Li Q, Sun J, Ma L, Ding Y, Cai Y, Iliuk A, Chen B, Xie Z, Tao WA, Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. Analyst, 148(15):3594-3602(2023) [pubmed]

Keyword List

submitter keyword: PCNSL, Human, CSF, EV, Phosphoproteome

submitter keyword: PCNSL, Human, CSF, EV, Phosphoproteome

Contact List

Weiguo Andy Tao
lab head
Yuanyuan Deng
contact affiliation	Southeast University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002076/