PXD040699
PXD040699 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deciphering the molecular mechanism of melatonin inducing osteogenic differentiation |
| Description | Melatonin (MT) has been proposed as a treatment for OP, but the therapeutic effect of this agent needs further validation and the mechanisms remain to be explored. In this study, we observed that MT markedly stimulated osteogenic differentiation of BMSCs, and alleviated OP symptoms in mice. To explore the molecular mechanism of MT regulating differentiation of BMSCs, the proteomics analyses were conducted, and the multiple important genes were found. Importantly, it was found that MT could promote expression of thioredoxin1 (TRX1) in vivo and in vitro conditions, while its expression notably decreased in osteoporotic mice, thereby suggesting this gene might mediate the therapeutic effect of MT on OP. Moreover, the following overexpression or silencing of TRX1 proved its ability to induce osteogenesis of BMSCs. Furthermore, osteogenic differentiation and OP after MT pretreatment was attenuated both in BMSCs and in mice with Trx1 knockdown. These findings confirm that TRX1 is potentially associated with the beneficial effects of MT and that the use of MT may reduce OP. |
| HostingRepository | iProX |
| AnnounceDate | 2023-03-08 |
| AnnouncementXML | Submission_2023-03-08_18:20:11.587.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiangqiang Ji |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-03-08 18:19:54 | ID requested | |
| ⏵ 1 | 2023-03-08 18:20:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Melatonin (MT);osteogenic differentiation of BMSCs;molecular mechanism; |
Contact List
| Zhaowei Teng | |
|---|---|
| contact affiliation | Kunming Medical University |
| contact email | tengzhaowei2003@163.com |
| lab head | |
| Qiangqiang Ji | |
| contact affiliation | Wuhan GeneCreate Biological Engineering Company |
| contact email | 3284640378@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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