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PXD040635

PXD040635 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSPARKEL depletion time course proteome
DescriptionApicomplexan parasites are ubiquitous pathogens of humans. Toxoplasma gondii, a model apicomplexan, possesses a divergent ortholog of mammalian PDK1. This ortholog, TgSPARK, is essential for the ability of parasites to invade and exit their host. We discovered an interactor of SPARK, an elogin-like protein that we termed SPARKEL. Here, we conduct a quantitative mass spectrometry experiment to measure changes to the parasite proteome following 0, 3, 8, and 24 hours of conditional SPARKEL depletion.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:49:37.475.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD040635
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAlice Herneisen
SpeciesList scientific name: Toxoplasma gondii GT1; NCBI TaxID: 507601;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue; phosphorylated residue; acetylated residue; monohydroxylated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-06 13:55:29ID requested
12024-10-08 11:36:04announced
22024-10-22 06:49:37announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD040635;
10.7554/ELIFE.93877.1;
Keyword List
submitter keyword: Toxoplasma gondii, parasite
Contact List
Sebastian Lourido
contact affiliationWhitehead Institute for Biomedical Research and Massachusetts Institute of Technology
contact emaillourido@wi.mit.edu
lab head
Alice Herneisen
contact affiliationWhitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology
contact emailalice@wi.mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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