PXD040622

PXD040622 is an original dataset announced via ProteomeXchange.

Title	Analysis of the cellular effect of 1α,25-dihydroxyvitamin D3 on lung NCI-H441 cells
Description	Low serum levels or deficiency of 1α,25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or acute respiratory distress syndrome, although the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, alveolar type II cell differentiation and pulmonary surfactant synthesis. This study aims to expand the knowledge by quantitative characterization of NCI-H441 cells upon VD3 treatment at the proteome level.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:47:51.191.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Tholey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-06 07:41:45	ID requested
1	2023-05-10 15:36:11	announced
⏵ 2	2023-11-14 08:47:52	announced	2023-11-14: Updated project metadata.

Xiong J, Kaleja P, Ü, ckert L, Nezaratizadeh N, Krantz S, Krause MF, Fitschen-Oestern S, Seekamp A, Cassidy L, Tholey A, Fuchs S, , 25-Dihydroxyvitamin D3. Int J Mol Sci, 24(8):(2023) [pubmed]

submitter keyword: Vitamin D3, NCI-H441 cells, alveolar-capillary barrier, lung, isobaric labelling, biomarker

Andreas Tholey
contact affiliation	Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
contact email	a.tholey@iem.uni-kiel.de
lab head
Andreas Tholey
contact affiliation	Systematic Proteome Research & Bioanalytics, University of Kiel
contact email	a.tholey@iem.uni-kiel.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD040622

PRIDE project URI

• PRIDE
  1. PXD040622
     1. Label: PRIDE project
     2. Name: Analysis of the cellular effect of 1α,25-dihydroxyvitamin D3 on lung NCI-H441 cells