PXD040598 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Protein abundances following 24h of SPARK depletion in Toxoplasma gondii |
Description | Toxoplasma gondii is a ubiquitous eukaryotic pathogen. Apicomplexan parasites-the family to which T. gondii belongs-possess a divergent ortholog of mammalian PDK1. We have previously shown that this store potentiating/activating regulatory kinase (SPARK) is essential for T. gondii motility, invasion, and egress. Here, we conditionally depleted SPARK in live parasites for 24 hours to determine the impact of SPARK function on the parasite proteome. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:49:30.312.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD040598 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Alice Herneisen |
SpeciesList | scientific name: Toxoplasma gondii GT1; NCBI TaxID: 507601; |
ModificationList | methylthiolated residue; acetylated residue; monohydroxylated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-05 08:35:17 | ID requested | |
1 | 2024-10-08 11:38:37 | announced | |
⏵ 2 | 2024-10-22 06:49:30 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Toxoplasma, PDK1, parasite |
Contact List
Sebastian Lourido |
contact affiliation | Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology |
contact email | lourido@wi.mit.edu |
lab head | |
Alice Herneisen |
contact affiliation | Whitehead Institute for Biomedical Research, Cambridge, MA, USA 02142 Department of Biology, Massachusetts Insitute of Technology |
contact email | alice@wi.mit.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040598
- Label: PRIDE project
- Name: Protein abundances following 24h of SPARK depletion in Toxoplasma gondii