PXD040582

PXD040582 is an original dataset announced via ProteomeXchange.

Title	Proteome characterization of HCMV virus microenvironment with addition of cidofovir
Description	The control of host processes which influence cell-cell communication is central to determining the outcome of a virus infection in tissue. Despite this, it remains unclear how cells either in close or distant proximity to an infected cell differentially respond to the primary infection. Here, we established a virus infection microenvironment to resolve molecular features and functional consequences of cell spatial address within this localized niche by mass spectrometry. To rule out the possibility that neighboring cells are infected by the viral progeny from the primary infection, cidofovir is added in the system to prevent viral genome replication in order to prevent the spread of infection.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:04.688.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bokai Song
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-03 08:48:11	ID requested
1	2023-05-11 11:54:41	announced
⏵ 2	2023-11-14 08:48:05	announced	2023-11-14: Updated project metadata.

Song B, Sheng X, Justice JL, Lum KK, Metzger PJ, Cook KC, Kostas JC, Cristea IM, Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections. Sci Adv, 9(19):eadg3433(2023) [pubmed]

submitter keyword: HCMV, innate immunity, membrane contact sites, mass spectrometry,virus microenvironment, cell cycle, cidofovir

Ileana Cristea
contact affiliation	Department of Molecular Biology, Princeton University
contact email	icristea@princeton.edu
lab head
Bokai Song
contact affiliation	Princeton University
contact email	bokais@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD040582

PRIDE project URI

• PRIDE
  1. PXD040582
     1. Label: PRIDE project
     2. Name: Proteome characterization of HCMV virus microenvironment with addition of cidofovir