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PXD040568

PXD040568 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMolecular control of endurance training adaptation in mouse skeletal muscle
DescriptionSkeletal muscle has an enormous plastic potential to adapt to various external and internal perturbations. While morphological changes in endurance trained muscles are well described, the molecular underpinnings of training adaptation are poorly understood. We aimed at defining the molecular signature of a trained muscle and unraveling the training status-dependent responses to an acute bout of exercise. Our results reveal that even though at baseline, the transcriptomes of trained and untrained muscles are very similar, training status substantially affects the transcriptional response to an acute challenge, both quantitatively and qualitatively, in part mediated by epigenetic modifications. Second, proteomic changes were elicited by different transcriptional modalities. Finally, an unexpected resilience to enhance endurance performance even in the absence of key regulatory factors was observed, suggesting a strong evolutionary pressure on enabling muscle plasticity even in unfavorable contexts. Together, these results provide a molecular framework that defines muscle plasticity in training.
HostingRepositoryMassIVE
AnnounceDate2025-02-25
AnnouncementXMLSubmission_2025-02-25_00:09:57.536.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdanilo ritz
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListOxidation; Carbamidomethyl; Acetyl
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-03 02:41:27ID requested
12025-02-25 00:09:57announced
Publication List
no publication
Keyword List
submitter keyword: exercise, training, transcription, epigenetic modifications, skeletal muscle, PGC-1-alpha
Contact List
Alexander Schmidt
contact affiliationBiozentrum, Universtiy of Basel, 4056 Basel, Switzerland
contact emailalex.schmidt@unibas.ch
lab head
danilo ritz
contact affiliationUniversity of Basel
contact emaildanilo.ritz@unibas.ch
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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