PXD040566

PXD040566 is an original dataset announced via ProteomeXchange.

Title	A proteomic profiling in Alzheimer's Disease to identify the disregulation of proteins and pathology
Description	The discovery of blood-based proteomics biomarkers is recently a popular topic in AD studies due to its advantage to relate external environmental factors with the development of AD. In this study, a proteomic study based on Malaysian Chinese and Malay prospects was conducted. Differentially expressed proteins (DEPs) in AD patients and normal controls for Chinese and Malays were identified. The dissimilarities of dysregulated proteins identified in Chinese and Malays samples suggested the differences of pathways involved in this pathological condition for each respective ethnicity: the Chinese group was involved to Aβ/tau protein-related, oxidative stress and inflammation whereas neuroinflammation was related to the Malays. These findings served as a preliminary understanding in the molecular studies of AD especially in multi-ethnic population.
HostingRepository	PRIDE
AnnounceDate	2024-06-10
AnnouncementXML	Submission_2024-06-09_19:08:11.947.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siow-Wee Chang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-03 00:49:22	ID requested
⏵ 1	2024-06-09 19:08:12	announced

Dataset with its publication pending

submitter keyword: Alzheimer's Disease

dysregulated proteins

LC-MS/MS

Siow-Wee Chang
contact affiliation	Institute of Biological Sciences, University of Malaya
contact email	siowwee@um.edu.my
lab head
Siow-Wee Chang
contact affiliation	Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Malaysia
contact email	siowwee@um.edu.my
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD040566
     1. Label: PRIDE project
     2. Name: A proteomic profiling in Alzheimer's Disease to identify the disregulation of proteins and pathology