PXD040544

PXD040544 is an original dataset announced via ProteomeXchange.

Title	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Description	Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for healthy immune system. Although some regulators of cGAS have been reported, it still remains largely unknown about how cGAS is precisely and dynamically regulated and how many potential regulators govern cGAS. Here we carry out proximity labeling of cGAS with TurboID in cells and identify a number of potential cGAS interacting or adjacent proteins.
HostingRepository	iProX
AnnounceDate	2023-03-02
AnnouncementXML	Submission_2023-03-26_23:21:05.082.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Heng Lyu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-01 23:41:36	ID requested
1	2023-03-01 23:41:50	announced
⏵ 2	2023-03-26 23:21:07	announced	2023-03-27: Update publication information.

Lyu H, Sun L, Guan Z, Li J, Yin C, Zhang Y, Jiang H, Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS. Cell Rep, 42(4):112309(2023) [pubmed]

submitter keyword: cGAS, Proximity Labeling

Hong Jiang
contact affiliation	Shanghai Institute of Organic Chemistry
contact email	hongjiang@sioc.ac.cn
lab head
Heng Lyu
contact affiliation	Shanghai Institute of Organic Chemistry
contact email	lvheng19941219@163.com
dataset submitter

iProX dataset URI