PXD040530 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Bleomycin model of fibrosis and resolution phase in old and young mice |
Description | Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Young (3 months) and old (21 months) mice were treated with Bleomycin or with control saline solution and analyzed transcript and protein expression over 8 weeks (Day 0, 14, 21, 28, 35, 42, 49, 56). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:57:56.857.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Daniel Veyel |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-03-01 09:22:13 | ID requested | |
1 | 2024-09-10 11:33:50 | announced | |
⏵ 2 | 2024-10-22 06:57:57 | announced | 2024-10-22: Updated project metadata. |
Publication List
Weckerle J, Mayr CH, Fundel-Clemens K, L, ä, mmle B, Boryn L, Thomas MJ, Bretschneider T, Luippold AH, Huber HJ, Viollet C, Rist W, Veyel D, Ramirez F, Klee S, K, ä, stle M, Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice. Am J Respir Cell Mol Biol, 69(4):422-440(2023) [pubmed] |
10.1165/rcmb.2023-0012oc; |
Keyword List
submitter keyword: Bleomycin, DIA,Mouse, lung, fibrosis, age |
Contact List
Wolfgang Rist |
contact affiliation | Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences |
contact email | wolfgang.rist@boehringer-ingelheim.com |
lab head | |
Daniel Veyel |
contact affiliation | Boehringer Ingelheim Pharma GmbH & Co. KG |
contact email | daniel.veyel@boehringer-ingelheim.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD040530 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040530
- Label: PRIDE project
- Name: Bleomycin model of fibrosis and resolution phase in old and young mice