PXD040471
PXD040471 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease (Whitehead data) |
| Description | Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we performed interaction proteomics for 11 CAD-risk genes to map their protein-protein interactions (PPIs) in human vascular cells and elucidate their biological relevance in CAD pathogenesis. The PPI networks contain many protein interactions that are outside of known biology in the vasculature and are enriched for genes involved in immunity-related and arterial-wall-specific mechanisms. Furthermore, several PPI networks derived from smooth muscle cells are significantly enriched for genetic variants associated with CAD and related vascular phenotypes. Finally, our networks identified 61 genes that are found in genetic loci associated with risk of CAD, prioritizing them as the causal candidates within these loci. Together, our results indicate that the PPI networks we have generated are a rich resource for guiding future research into the molecular pathogenesis of CAD. |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-10-03 |
| AnnouncementXML | Submission_2023-10-03_14:27:31.608.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lage Lab |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Oxidation; Deamidated; Phospho; Acetyl; iTRAQ4plex; TMT6plex |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-02-27 08:44:46 | ID requested | |
| ⏵ 1 | 2023-10-03 14:27:31 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: coronary artery disease, protein-protein interaction, human aortic endothelial cells, human coronary artery smooth muscle cells |
Contact List
| Kasper Lage | |
|---|---|
| contact affiliation | Massachusetts General Hospital |
| contact email | klhansen@broadinstitute.org |
| lab head | |
| Lage Lab | |
| contact affiliation | Broad Institute of MIT and Harvard |
| contact email | klagelab@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000091373/ |
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