PXD040424

PXD040424 is an original dataset announced via ProteomeXchange.

Title	Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development
Description	Pax5 controls B-cell commitment, development and immunity by repressing B-lineage-inappropriate genes and activating B-cell-specific genes. In addition to the N-terminal DNA-binding paired domain, Pax5 contains a conserved octapeptide, partial homeodomain and C-terminal sequences with transactivating and inhibitory potential. To understand how the C-terminal domains of Pax5 contribute to the repression and activation function of Pax5, we performed Pax5 pulldown combined with mass spectrometry to identify coactivator or corepressor complexes that bind to the C-terminal regions of Pax5.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:13:35.264.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Richard Imre
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-27 05:18:36	ID requested
1	2023-08-24 00:58:00	announced
⏵ 2	2023-11-14 07:13:35	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: co-repressors, C-terminal regulatory domains, gene activation, co-activators,Pax5, gene repression

Meinrad Busslinger
contact affiliation	Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC)
contact email	busslinger@imp.ac.at
lab head
Richard Imre
contact affiliation	IMBA Vienna
contact email	richard.imre@imba.oeaw.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD040424

PRIDE project URI

• PRIDE
  1. PXD040424
     1. Label: PRIDE project
     2. Name: Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development