PXD040417

PXD040417 is an original dataset announced via ProteomeXchange.

Title	Mode-of-Action Studies using PfHsp90-Binding Molecules with Anti-Malarial Activity
Description	Two PfHsp90-binding molecules, BX2819 and HS292 that have and do not have (respectively) biological activity against the blood and liver stages of Plasmodium Falciparum, were subjected to a Thermal Proteome Profiling analysis to identify the direct and indirect protein target of these molecules.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:23:12.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Morgan Bailey
SpeciesList	scientific name: Plasmodium falciparum (isolate 3D7); NCBI TaxID: 36329;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue; acetylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-27 05:12:04	ID requested
1	2024-01-17 08:29:31	announced
⏵ 2	2024-10-22 06:23:13	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Anti-Malaria, Plasmodium Falciparum, Hsp90, Thermal Proteome Profile

Dr. Michael C. Fitzgerald
contact affiliation	Professor, Department of Chemistry, Duke University, USA
contact email	michael.c.fitzgerald@duke.edu
lab head
Morgan Bailey
contact affiliation	Duke University Department of Chemistry
contact email	morgan.a.bailey@duke.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD040417

PRIDE project URI

• PRIDE
  1. PXD040417
     1. Label: PRIDE project
     2. Name: Mode-of-Action Studies using PfHsp90-Binding Molecules with Anti-Malarial Activity