PXD040403

PXD040403 is an original dataset announced via ProteomeXchange.

Title	KA120 negatively regulate immunity through inhibit MOS 4-associated-complex forming nuclear condensates
Description	To understand how KA120 participates in plant immune regulation as a karyopherin-β, we sought to determine in vivo substrates of KA120. We leveraged an enzyme-catalyzed proximity-labeling strategy, in which we fused KA120 with TurboID. MAC3B could form nuclear condensates in ka120 mutant thus cause aberrant immune response. To investigate how the MAC function may be altered upon condensation and how that may contribute to immune activation, we profiled the composition of the MAC in the presence and absence of KA120.
HostingRepository	iProX
AnnounceDate	2023-02-23
AnnouncementXML	Submission_2023-10-08_19:38:44.365.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuanyi Chen
SpeciesList	scientific name: Arabidopsis thaliana; NCBI TaxID: 3702;
ModificationList	biotinylated residue
Instrument	timsTOF Pro; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-26 19:15:14	ID requested
1	2023-02-28 17:53:47	announced
⏵ 2	2023-10-08 19:38:45	announced	2023-10-09: Update publication information.

Jia M, Chen X, Shi X, Fang Y, Gu Y, Nuclear transport receptor KA120 regulates molecular condensation of MAC3 to coordinate plant immune activation. Cell Host Microbe, 31(10):1685-1699.e7(2023) [pubmed]

submitter keyword: Arabidopsis thaliana, seedling, KA120, MAC3B, TurboID

Yangnan Gu
contact affiliation	Department of Plant & Microbial Biology, University of California, Berkeley
contact email	guyangnan@berkeley.edu
lab head
Xuanyi Chen
contact affiliation	College of Life Sciences, Northwest A&F University
contact email	chenxuanyi@nwafu.edu.cn
dataset submitter

iProX dataset URI