PXD040399

PXD040399 is an original dataset announced via ProteomeXchange.

Title	Systemic LRG1 expression in melanoma is associated with disease progression and recurrence
Description	Treatment of late-stage melanoma patients with immune checkpoint blockade (ICB) is currently one of the most effective standard therapies. The response rates upon neoadjuvant ICB in stage III melanoma are higher as compared to stage IV disease. Given that successful ICB depends on systemic immune response, we hypothesized that systemic immune suppression might be a mechanism responsible for lower response rates in late-stage disease, and also potentially with disease recurrence in early-stage disease.
HostingRepository	PRIDE
AnnounceDate	2024-01-09
AnnouncementXML	Submission_2024-01-09_09:11:28.326.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Robert Mosen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-26 10:01:41	ID requested
⏵ 1	2024-01-09 09:11:31	announced

Ludke RL, Westhoff LJ, Flood BM, Rural hospitals' viability and strategic responses. Health Prog, 73(4):49-53, 75(1992) [pubmed]

submitter keyword: LRG1, melanoma, systemic immune suppression,serum, checkpoint inhibitor

Christian Blank
contact affiliation	Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands
contact email	c.blank@nki.nl
lab head
Peter Robert Mosen
contact affiliation	Utrecht University Biomolecular Mass Spectrometry and Proteomics Padualaan 8, 3584 CH Utrecht
contact email	p.r.mosen@uu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD040399

PRIDE project URI

• PRIDE
  1. PXD040399
     1. Label: PRIDE project
     2. Name: Systemic LRG1 expression in melanoma is associated with disease progression and recurrence