PXD040382 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome analysis of mouse cerebellar synaptosomes |
Description | In this study we have compared the proteomes from cerebellar synaptosome of early symptomatic Cstb-/- and wild type mice to gain insight into disease onset and progression of cystatin B deficiency. Biallelic loss-of-function mutations in the CSTB gene cause progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1). In the mouse model of EPM1, CSTB deficiency manifests from one month of age as progressive neurodegeneration, myoclonus and ataxia, which is preceded by neuroinflammation, alterations in GABAergic signaling, and a widespread rearrangement of the mitochondrial proteome in synapses. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:56:21.230.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tuula Nyman |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-02-24 04:20:45 | ID requested | |
1 | 2023-07-20 11:34:50 | announced | |
2 | 2023-11-14 09:03:24 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:56:22 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.3389/fnmol.2023.1175851; |
Gorski K, Jackson CB, Nyman TA, Rezov V, Battersby BJ, Lehesjoki AE, Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice. Front Mol Neurosci, 16():1175851(2023) [pubmed] |
Keyword List
submitter keyword: cerebellum, cystatin B, mouse,synaptosome, LC-MS/MS |
Contact List
Tuula Nyman |
contact affiliation | Head of Proteomics |
contact email | tuula.nyman@medisin.uio.no |
lab head | |
Tuula Nyman |
contact affiliation | University of Oslo |
contact email | tuula.nyman@medisin.uio.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD040382 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040382
- Label: PRIDE project
- Name: Proteome analysis of mouse cerebellar synaptosomes