PXD040359

PXD040359 is an original dataset announced via ProteomeXchange.

Title	A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites
Description	The development of safe anti-infectives requires strategies focusing on pathways solely present in pathogens. Following this principle, we here developed inhibitors of lipoic acid (LA) salvage which is crucial for the survival of LA auxotroph bacteria and parasites but non-essential in human cells. An LA based probe was effectively transferred on substrate proteins via lipoate protein ligase (LPL) and hence, their binding sites determined by mass-spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:49:22.259.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan-Niklas Dienemann
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Listeria monocytogenes EGD-e; NCBI TaxID: 169963;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-23 03:57:01	ID requested
1	2023-06-21 00:35:08	announced
2	2023-11-14 06:45:27	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:49:22	announced	2024-10-22: Updated project metadata.

10.1002/ANIE.202304533;

submitter keyword: Lipoylation, Probe, Lipoic acid, Cofactor

Dr Stephan A. Sieber
contact affiliation	Technical University of Munich, Germany; TUM School of Natural Sciences, Department of Bioscience; Center for Functional Protein Assemblies (CPA)
contact email	stephan.sieber@tum.de
lab head
Jan-Niklas Dienemann
contact affiliation	Technical University of Munich, Germany; TUM School of Natural Sciences, Department of Bioscience; Center for Functional Protein Assemblies (CPA)
contact email	jan-niklas.dienemann@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD040359

PRIDE project URI

• PRIDE
  1. PXD040359
     1. Label: PRIDE project
     2. Name: A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites