PXD040305

PXD040305 is an original dataset announced via ProteomeXchange.

Title	Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
Description	Intrauterine exposure to disturbed maternal glucose metabolism is associated with adverse consequences for the offspring. Hepatic disorders in affected offspring emerge in early development; thus, detection of disease biomarkers at an early stage may elucidate the underlying mechanisms of maternal hyperglycemia-induced metabolic disease and improve timely diagnosis and treatment strategies. To systematically study the molecular consequences of maternal hyperglycemia, we used data independent acquisition (DIA) proteomics and compared the molecular profiles of liver of three days old wild-type piglets born to a transgenic hyperglycemic pig model with those of wild-type piglets born to normoglycemic mothers.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:02:07.177.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bachuki Shashikadze
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-21 02:43:59	ID requested
1	2023-07-10 12:37:25	announced
⏵ 2	2023-11-14 09:02:14	announced	2023-11-14: Updated project metadata.

Shashikadze B, Valla L, Lombardo SD, Prehn C, Haid M, Riols F, St, ö, ckl JB, Elkhateib R, Renner S, Rathkolb B, Menche J, Hrab, ĕ, de Angelis M, Wolf E, Kemter E, Fr, ö, hlich T, Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model. Mol Metab, 75():101768(2023) [pubmed]

submitter keyword: Maternal diabetes, proteomics, metabolomics, liver, protein-protein interaction, clinical parameters, pig model, neonates

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	Frohlich@genzentrum.lmu.de
lab head
Bachuki Shashikadze
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	shashikadze@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD040305

PRIDE project URI

• PRIDE
  1. PXD040305
     1. Label: PRIDE project
     2. Name: Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model