PXD040301
PXD040301 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1 |
Description | Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To map the ubiquitination site of RIPK1 regulated by PPDPF, we performed MS analysis using control and RIPK1-overexpressing HEK293T cells with or without PPDPF overexpression |
HostingRepository | iProX |
AnnounceDate | 2023-02-21 |
AnnouncementXML | Submission_2024-06-06_01:11:59.959.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yikang Wang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | ubiquitination signature dipeptidyl lysine |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-02-20 22:50:31 | ID requested | |
1 | 2023-02-20 22:51:07 | announced | |
⏵ 2 | 2024-06-06 01:12:00 | announced | 2024-06-06: Update information. |
Publication List
Wang YK, Ma N, Xu S, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng SQ, Xie D, Li JJ, PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1. Cell Rep, 42(4):112340(2023) [pubmed] |
Keyword List
submitter keyword: Ubiquitination, RIPK1, LCMS, 293T |
Contact List
Jingjing Li | |
---|---|
contact affiliation | Shanghai Institute of Nutrition and Health |
contact email | tide7@163.com |
lab head | |
Yikang Wang | |
contact affiliation | Shanghai Institute of Nutrition and Health |
contact email | wangyikang2017@sibs.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |