PXD040301
PXD040301 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1 |
Description | Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To map the ubiquitination site of RIPK1 regulated by PPDPF, we performed MS analysis using control and RIPK1-overexpressing HEK293T cells with or without PPDPF overexpression |
HostingRepository | iProX |
AnnounceDate | 2023-02-21 |
AnnouncementXML | Submission_2023-02-20_22:51:06.706.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yikang Wang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | ubiquitination signature dipeptidyl lysine |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-02-20 22:50:31 | ID requested | |
⏵ 1 | 2023-02-20 22:51:07 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Ubiquitination,RIPK1,LCMS,293T |
Contact List
Jingjing Li | |
---|---|
contact affiliation | Shanghai Institute of Nutrition and Health |
contact email | tide7@163.com |
lab head | |
Yikang Wang | |
contact affiliation | Shanghai Institute of Nutrition and Health |
contact email | wangyikang2017@sibs.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |