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PXD040263

PXD040263 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMitochondrial folate one-carbon metabolism moderates Alzheimer’s disease pathology
DescriptionFamilial forms of AD cause a loss of neurons associated with the accumulation of toxic amyloid β peptide (Aβ) and mitochondrial dysfunction. We found that flies over expressing a toxic form of Aβ (Aβ-Arc) exhibit altered components of mitochondrial complex I and one-carbon (1C) metabolism.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_09:22:09.303.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLuis Martins
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-02-20 04:53:57ID requested
12025-05-06 09:22:10announced
Publication List
10.1038/s41419-024-07179-3;
Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, Leal NS, Popovic R, Loh SHY, Martins LM, Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis, 15(11):856(2024) [pubmed]
Keyword List
submitter keyword: amyloid-beta, mitochondria, Drosophila,Alzheimer's disease
Contact List
L. Miguel Martins
contact affiliationMRC Toxicology Unit, University of Cambridge
contact emaillm795@cam.ac.uk
lab head
Luis Martins
contact affiliationUniversity of Cambridge
contact emailmartins.lmiguel@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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