PXD040263 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mitochondrial folate one-carbon metabolism moderates Alzheimer’s disease pathology |
Description | Familial forms of AD cause a loss of neurons associated with the accumulation of toxic amyloid β peptide (Aβ) and mitochondrial dysfunction. We found that flies over expressing a toxic form of Aβ (Aβ-Arc) exhibit altered components of mitochondrial complex I and one-carbon (1C) metabolism. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-06 |
AnnouncementXML | Submission_2025-05-06_09:22:09.303.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luis Martins |
SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-02-20 04:53:57 | ID requested | |
⏵ 1 | 2025-05-06 09:22:10 | announced | |
Publication List
10.1038/s41419-024-07179-3; |
Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, Leal NS, Popovic R, Loh SHY, Martins LM, Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis, 15(11):856(2024) [pubmed] |
Keyword List
submitter keyword: amyloid-beta, mitochondria, Drosophila,Alzheimer's disease |
Contact List
L. Miguel Martins |
contact affiliation | MRC Toxicology Unit, University of Cambridge |
contact email | lm795@cam.ac.uk |
lab head | |
Luis Martins |
contact affiliation | University of Cambridge |
contact email | martins.lmiguel@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040263 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD040263
- Label: PRIDE project
- Name: Mitochondrial folate one-carbon metabolism moderates Alzheimer’s disease pathology