PXD040263

PXD040263 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mitochondrial folate one-carbon metabolism moderates Alzheimer’s disease pathology
Description	Familial forms of AD cause a loss of neurons associated with the accumulation of toxic amyloid β peptide (Aβ) and mitochondrial dysfunction. We found that flies over expressing a toxic form of Aβ (Aβ-Arc) exhibit altered components of mitochondrial complex I and one-carbon (1C) metabolism.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:22:09.303.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luis Martins
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-20 04:53:57	ID requested
⏵ 1	2025-05-06 09:22:10	announced

Publication List

10.1038/s41419-024-07179-3;
Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, Leal NS, Popovic R, Loh SHY, Martins LM, Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis, 15(11):856(2024) [pubmed]

10.1038/s41419-024-07179-3;

Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, Leal NS, Popovic R, Loh SHY, Martins LM, Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis, 15(11):856(2024) [pubmed]

Keyword List

submitter keyword: amyloid-beta, mitochondria, Drosophila,Alzheimer's disease

submitter keyword: amyloid-beta, mitochondria, Drosophila,Alzheimer's disease

Contact List

L. Miguel Martins
contact affiliation	MRC Toxicology Unit, University of Cambridge
contact email	lm795@cam.ac.uk
lab head
Luis Martins
contact affiliation	University of Cambridge
contact email	martins.lmiguel@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040263
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD040263

PRIDE project URI

Repository Record List

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